“NovoRetin” is an active ingredient developed by a Swiss company that specializes in the research and development of innovative cosmetic and skincare ingredients. 


NovoRetin is designed to provide benefits similar to those of traditional retinoids, such as retinol, but with potentially fewer side effects and less skin sensitivity. It is often marketed as a retinol alternative for individuals who may be sensitive to or experience irritation from traditional retinoids. NovoRetin is said to offer the following skincare benefits:


  • Skin renewal: NovoRetin is designed to promote cell turnover and stimulate the skin’s natural renewal processes, which can help improve the appearance of fine lines and wrinkles.
  • Improved skin texture: Like traditional retinoids, NovoRetin may help refine skin texture and promote a smoother complexion.
  • Anti-aging: It is used for its anti-aging properties, assisting in reducing the signs of aging on the skin.
  • Reduction of hyperpigmentation: NovoRetin may help with reducing the appearance of dark spots and hyperpigmentation.
  • Less potential for irritation: One of the key selling points is that NovoRetin is marketed as a more gentle alternative to traditional retinoids, potentially causing less irritation and redness.

Since the specific formulation and properties of NovoRetin may vary depending on the product and brand that uses it, I would recommend consulting the manufacturer’s or brand’s website or contacting them directly for detailed information on the NovoRetin-containing products and their specific benefits.


Chios Mastic  2.3%
Lecithin  2%
Pentylene Glycol  2.7%
Glyceryl Caprylate  0.3%
Caprylic/ Capric Triglyceride Deionized Water   12.7%

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NovoRetinTM (standard version, COSMOS approved*, NATRUE approved): Pistacia Lentiscus Gum / Pistacia Lentiscus (Mastic) Gum (and) Lecithin (and) Pentylene Glycol (and) Glyceryl Caprylate / Caprate (and) Caprylic / Capric Triglyceride (and) Aqua / Water

NovoRetinTM O (oil-soluble version, COSMOS approved*, NATRUE approved): Pistacia Lentiscus Gum / Pistacia Lentiscus (Mastic) Gum(and) Caprylic / Capric Triglyceride

Chios Mastic

Chios mastiha, also known as mastic gum, is a unique and aromatic resin obtained from the mastic tree (Pistacia lentiscus var. Chia) primarily grown on the Greek island of Chios. It has been used for various purposes for centuries and is known for its distinctive flavor and therapeutic properties. Here are some key aspects of Chios mastiha:

  1. Flavor and Aroma: Chios mastiha has a unique, sweet, and slightly piney flavor, along with a pleasant aromatic scent. This unique flavor is often used in a variety of culinary applications.

  2. Culinary Use: Chios mastiha is a popular ingredient in Greek and Mediterranean cuisine. It is often used to flavor desserts, baked goods, ice cream, and beverages. It can be added to recipes as a spice or used to make a traditional liqueur called “Mastiha liqueur.”

  3. Medicinal and Therapeutic Uses: Chios mastiha has been used in traditional medicine for various purposes, including as a digestive aid, to treat stomach issues, and as a remedy for oral health. It is sometimes used in the production of natural supplements and cosmetics.

  4. Chewing Gum: Chios mastiha resin is traditionally chewed as a gum, offering potential benefits for oral hygiene and digestion. Chewing the resin has been practiced for centuries as a custom in certain regions.

  5. Cosmetic and Skincare Products: Mastiha is often used in the cosmetics industry to make skincare products, such as lotions, creams, and soaps, due to its potential skin-soothing and anti-inflammatory properties.

  6. Protected Designation of Origin (PDO): Chios mastiha is a PDO product, meaning it is protected by European Union regulations to ensure that only products produced in the designated region of Chios can bear the name “Chios mastiha.”

Chios mastiha has a rich history and cultural significance on the island of Chios, and it continues to be valued for its culinary and medicinal properties both locally and internationally.

Retinoic Acid Boosting Effect

  • The new active is based on an endogenous process that is present in every cell in our body: Vitamin A (retinol) is ingested through food  break down to retinoic acid if required.

  • In the cells, retinoic acid induces its own degradation by activating an enzyme of the CYP26 family.

  • In skin the enzyme CYP26A1 is responsible for the elimination of retinoic acid.

    — By inhibiting CYP26A1 enzyme, it is possible to increase the endogenous levels of retinoic acid in the skin.—

  • NovoRetinTM clearly enhanced the abundance of involucrin in the epidermis compared to control.

  • NovoRetinTM has a retinoic acid boosting effect that is similar to the effect of the CYP26 inhibitor talarozole.

    —Topical application of NovoRetinTM can enhance retinoic acid levels in the skin.—

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